In the Nintendo Switch port, references to drugs are censored by referring to them as "magicals" and "sweets." Consequently, several drugs that Ame can take throughout the game are renamed to fit this theme, though their function as stand-ins for real-world prescription, over-the-counter, and recreational substances are unchanged:

• Depaz (Prozac antidepressants) is renamed Magical Macarons.
• Dylsem (Deslym cough medicine) is renamed Magical Cookies.
• Embian (Ambien) is renamed Magical Cake.
• Magic Grass (marijuana) is renamed Magical Cigarettes.
• Magic Paper (LSD) is renamed Magical Candy.

Similarly, all instances of the words "sex" and "sexy" are replaced with "❤❤❤" (though all other instances of sexually charged language and sexual content are unchanged). It is unknown if the changes were requested by Nintendo or if they were done at the behest of the Computer Entertainment Rating Organization (CERO) to permit a console release.

In the South Korean release of the game, the character sprites in "Samurai Kirby" are edited to remove Japanese cultural elements. These changes are owed to widespread anti-Japanese sentiment in South Korea following a 35-year period from 1910 to 1945 where the Korean peninsula was occupied and culturally assimilated by the Japanese Empire. After this period ended, Japanese cultural imports were banned in South Korea for almost 60 years, and while most restrictions were gradually rescinded by 2004, some remain in place.

The manga adaptation of The Legend of Zelda: Ocarina of Time features a race of bird-like humanoids called the Watatara. According to series producer Eiji Aonuma in a 2005 interview with the magazine "Nintendo Dream", the Watatara later inspired the Rito, a similar race of bird people that debuted in The Legend of Zelda: The Wind Waker.

Several unused sprites for an Acorn Baki exist within the game files, including various hurt sprites. This suggests that enemies were originally going to use sprites in the game's levels, rather than the digitally-drawn "toys" used in the final game.

Within the game's data is an incomplete cutscene depicting Anton interrupting Satan's game of Pachinko; the sequence is fully animated and voice acted, but lacks sound effects. The sign on top of the Pachinko machine, "PaFREAKO," indicates that the cutscene was likely intended to precede the Freako Dragon fight.

Meat Boy from Super Meat Boy makes cameo appearances in the World 3 level Gall Blaster and in that world's boss, The Source. His appearance is further addressed in the game's final cutscene where he is shown alongside multiple original characters, teasing Bit.Trip Fate. As a result, the Wii version of the game marks Meat Boy's first appearance on a Nintendo console, as Super Meat Boy would not be ported to one (the Wii U) until six years later.

In the English dub, at the end of a possible Mementos conversation in the Path of Da'at, Ryuji makes a coughing sound. Max Mittelman, Ryuji's voice actor, explained on a livestream that he did not remember exactly why he made that sound, but that it was likely because he was almost out of breath. Since the sound is not typed out in the game's text, it was presumably left in by mistake.

In an interview with GamesRadar+, creative director George Andreas revealed that the game's notoriously high volume of collectibles was the result of an executive request from Rare co-founder Tim Stamper. According to Andreas, Stamper believed that the emphasis on collectables would help differentiate the game from Banjo-Kazooie, which the Stamper brothers had previously produced. This desire also influenced the decision to feature five playable characters and the inclusion of "thrilling moments" such as mine cart and slide segments.

The game features a cheat code system accessible via the Options menu, but seemingly none of the codes were ever shared, instead being found by loading "main.dol" into a hex editor when starting at offset 00546F00. The codes in question are:

• "disney fanatic" (unlocking the Fun Pack clothing items)
• "mega star" (unlocking the Wacky Pack clothing items)
• "unlockminigames" (unlocking all the minigames)
• "unlockcawparts" (unlocking all the closet clothing items except the two packs above)
• "unlockall" (unlocking everything except the two packs above)

If the player enters "disney fanatic" or "mega star", a dialogue box will be displayed informing the player that they have unlocked their respective packs. Given that the other codes simply play a chime when entered, it's possible that these two codes were planned for some sort of promotional event that never occurred. Additionally, another code is listed called "unlockmiis", which presumably would have unlocked the ability for players to play as their Mii characters. While the player can still unlock this by entering the "unlockall" code, entering the "unlockmiis" code will act as if it is invalid.

The opening lines to the song "Idle Hands (The Mysterious Glasshouse)" feature the lyric "Check it out, I'm in the house like carpet." This is a reference to the same opening line of the song "Burning Men's Soul" from the soundtrack to "Persona: Trinity Soul", an anime based on the Persona series.

Although the voices of the fighters are uncredited in-game, Nintendo has confirmed the majority of them through the official ARMS Twitter account:

• Peter Von Gomm voices Spring Man (and by extension Springtron).
• Momoka Kawasaki voices Ribbon Girl.
• Kenji Takahashi voices Ninjara.
• Kouji Takeda voices Master Mummy.
• Haruna Takatsu voices Min Min.
• Ayumi Fujimura voices Mechanica.
• Adeyto voices Twintelle.
• Ryouta Takeuchi voices Kid Cobra.
• Dominic Allen voices Max Brass.
• Soness Stevens voices Lola Pop.
• Toru Sakurai voices Misango.
• Donna Burke voices Dr. Coyle.

The remaining two fighters, Helix and Byte & Barq, are the only ones to have unknown voice actors. Coincidentally, they are also the only fully original non-human fighters.

The location test version of Beatmania IIDX 17 Sirius uses a different, earlier version of the song "Red. by Full Metal Jacket" than what is heard in the final game. While the scratches and samples are the same, the melody is completely different, instead being based on the song "CHANGE", a different song by artist DJ Mass MAD Izm*.

Originally, the game was titled "Don't Escape: 4 Days in a Wasteland". However, the game's title was changed when inXile Entertainment contacted Armor Games Studios and asked them to change it to avoid brand confusion, as they owned the trademark for the term "Wasteland" and were actively developing Wasteland 3 at the time.

During Course 5, Hole 6, players can find the Flatwoods monster (an alleged alien creature reported to have been sighted in the town of Flatwoods, West Virginia, USA) in the background between the trees. If the player zooms in too much, the alien will disappear.

In the 2008 film "The Rocker", several characters are shown playing or learning to play Rock Band. One of the fictional bands featured at the start of the movie, Vesuvius, performs a song called "Promised Land". As part of a promotional tie-in with the movie, this song was made available as a free DLC track on Rock Band Network in June 2008, but has since been delisted.

In Beatmania IIDX 7th Style's Single 7th Dan course, the Hyper Chart for "THE SAFARI", a song from Beatmania IIDX 6th Style, acts as the final song. However, many players felt that the chart was significantly harder than the other three proceeding it, to the point that some skipped directly to the Single 8th Dan course due to its final song being considered easier. The game's Japanese fan community started jokingly referring to players who do this as "Safari Refugees" (サファリ難民), which resulted in there being few Single 7th Dan course players overall. This has led to a running gag in which "THE SAFARI" has been the final song in the Single 7th Dan courses of every subsequent entry in the Beatmania series since.

Handheld ports of the game for the Nintendo 3DS and PlayStation Vita were planned after a $3.5 million dollar stretch goal for the game's Kickstarter campaign was reached. The ports were passed around to two different developers, Abstraction Games and Engine Software, but their development was marred by issues preventing Unreal Engine 3 from running on the 3DS, a botched attempt at a demake of the game, and delayed communication issues with developer Comcept. Despite work on the ports eventually dying down in 2017, Comcept never formally announced they were cancelled, with their last update claiming they would be released at the end of that year.

The United Kingdom branch of online retailer Amazon would continue accepting pre-orders for the unreleased 3DS port for over eight years despite it being listed as unavailable in other regions, while the PS Vita port was never available to pre-order. This availability period surpasses the game's release on other platforms in 2016, Comcept's acquisition by Level-5 in 2017, and the discontinuation of the consoles the ports were planned for. The listing most likely stayed up for that long because the branch was simply unaware of the port's development ending and nobody bothered to inform them. It wouldn't be until 2025 that Amazon UK finally listed the 3DS port as being out of stock and started issuing order cancellations, with the order drawing attention to this having originally been placed in 2022.

In all three of the Generation II Pokémon games, both shiny Pokémon and Unown forms are determined by IV values. Because of this, it is impossible to encounter a shiny Unown in any form other than, coincidentally, I or V. Sprites for Unown's other 24 forms are present in the game's code, but they all go unused because of this programming method. Furthermore, this is the only instance of true unused shiny Pokémon in the Generation II titles, as the placeholder shiny palette for the Pokémon egg is simply a duplicate of its normal palette.

This is the first game in the Professor Layton series to not feature Maki Horikita as the Japanese voice of Luke Triton, as she had retired from acting in 2017. She is replaced by Mio Imada in the game.