Three of the game's V.I.P. Bots are not based on video game characters, and are instead references to non-gaming products made by Sony. The Bots in question are "Forgotten Mascot" (based on Polygon Man, the intended mascot of the original PlayStation), "Pup Pal" and "Pup Pal +" (respectively based on the ERS-110 and ERS-1000 from AIBO, a series of robot dogs designed and manufactured by Sony).

The game is loosely based on the H. P. Lovecraft novella "The Shadow over Innsmouth". Lead developer Joseph "Akabaka" Hunter struggled to adapt this story as modern scholarly interpretations of Lovecraft's works frequently make accusations of racist and anti-miscegenation allegories in accordance with what is known about his personal views. While the original story (like most of Lovecraft's works) attempts to play into the fear of the unknown, Hunter felt the monsters and creatures used were "just, you know, metaphors for the guy living down the street, which is hardly unknown." Hunter did not want to potentially alienate players, and in order to adapt the story without reproducing these aspects, he took inspiration from "Lovecraft Country", a 2016 horror novel that adapted the Lovecraft mythos by using the controversial themes present in the original works to portray the experiences and threats black people faced in the United States under the Jim Crow laws.

All three games in the Pilotwings series were launch titles for different Nintendo consoles in various regions, acting as a sort of tech demo for their respective systems. The original Pilotwings was a launch title for the SNES in North America, Pilotwings 64 was a launch title for the Nintendo 64 in both Japan and North America, and Pilotwings Resort was a Nintendo 3DS launch title in Europe and the United States.

When wearing the NieR: Automata Nano Suits added in the crossover DLC with the game, if you attempt to move the camera to look up Eve's dress, a special animation will play where she notices and violently kicks the camera back away. This animation can only be triggered while wearing the NieR: Automata suits and none of the default suits in the base game, and acts as a reference to secret achievements in NieR RepliCant and NieR: Automata for trying to look under Kainé and 2B's clothes respectively.

Vs. Ice Climber and its NES port were the first games that programmer Kazuaki Morita worked on at Nintendo. In a 2006 interview, he said that he considered the game to be a "warm-up on the NES" prior to working on Super Mario Bros.

The Famicom version of Nuts & Milk was the first third party game on the platform. In the process of being ported to the Famicom, the game was overhauled from a top-down maze game comparable to Pac-Man to a 2D platformer comparable to Donkey Kong.

In the original version of Amanda the Adventurer (retroactively renamed to Amanda the Adventurer: Pilot Episode after being picked up by DreadXP to become a full game), Amanda was voiced by Chelsea Lecompte due to the game having to be made in a single week as part of "DreadXP's Found Footage Jam" and being easy to cast as she lived with the main developer. When the game was picked up for full funding, it was decided to recast her in favor of Blair Greene-Osako, as Amanda was a black character (something proposed during the design process) yet was voiced by a white actress in the game jam version. While they felt it was acceptable at the time given the circumstances, they decided to recast her with a black actress once those circumstances had changed. Despite this, Lecompte does still provide voice work for the full game, specifically as the Say n' See toy and Gret-chan the doll.

On the password screen, if you enter the password Pingu, Snowman, Dad, and Mom, the player will be brought to a screen where Pingu is seen dancing on a stage to the 1984 song "Woodpeckers from Space" by Eurodisco duo VideoKids. This song was previously featured in the original release of "Pingu Looks After the Egg", the second episode of the "Pingu" TV series in 1990.

Upon reaching Nuisance level with Lustat, one of her dialogue lines will have her claim that the player isn't "the cutest vampire slayer I've ever met", stating "There was this one gal in the 90s that... Well, best not to kiss and tell." This is a reference to the 1997 television series "Buffy the Vampire Slayer".

The model numbers of the Game & Watch titles Donkey Kong Circus and Mickey Mouse (Panorama) appear to have been flipped by mistake, as Donkey Kong Circus has the model number "MK-96" while Mickey Mouse has "DC-95".

Pinball was the first released Nintendo game that was programmed by future president and CEO Satoru Iwata. Although he had previously worked on a Famicom port for Joust, the port ended up being released in 1987, years after Pinball.

Unlike past titles in the Life is Strange series, Double Exposure is a direct sequel to the original game. In order to respect both of the first game's endings, players are given the option to choose an ending organically rather than making one of the two endings canon. Game director Jon Stauder elaborated on this, stating:

According to Ikuko Mimori, the sound designer for Pokémon Snap, two songs and an accompanying stage were scrapped from the game. Based on the names of the tracks ("Fantastic Horror" and "Theme of the Horror Boss"), it seems that the stage would likely have featured a Haunted or Ghost type theme. Concept art featured in the Pokémon Snap Official Strategy Guide portrays an early version of the game's setting, Pokémon Island, with an additional town and what appears to be a chapel, neither of which appear in the final game. This may be a depiction of the same cut stage, as "Fantastic Horror" uses bells that could be mounted in this chapel.

To promote the release of the game, HoYoverse collaborated with the YouTube channel Lofi Girl to release a Zenless Zone Zero-themed video featuring the character Belle on the HoYoFair YouTube channel. Similar to Lofi Girl's content, the video features lo-fi remixes of select songs from the game's soundtrack.

An unused, fully playable, ARM exists within the game's files under the name "GumShield." This ARM functions similarly to the Clapback, except incoming attacks stick to it instead of being reflected. The GumShield model also features a unique brand that went completely unused in the final game.

A Game Boy Advance version of the game was planned, but was scrapped for unknown reasons.

There is an apartment complex in front of an alleyway located a short distance from Toro's hotel room. If you visit this location in the evening, you can see in one of the second floor windows (the cursor pointing at it in the attached screenshot) what appears to be a giant ghostly face covering the whole window. This phenomenon seems to be addressed in a dialogue the player can have with Toro either directly in front of the building or heading up the stairs in the alleyway leading to it:


The discovery of this secret shortly after the game's release caused speculation among Japanese players as to if it was an intentional Easter egg, or a case of poor lighting inside the building, but the answer remains unknown.

A different version of the game was released in other Asian countries, including Hong Kong, that contained an English translation, making it the first Doko Demo Issyo game to be officially released in English.