The character R. Mika will give herself a buttslap right after activating her Critical Art. In early footage of the game, the camera focused on R. Mika's butt while this happened, but this was later changed so that the camera is repositioned higher up to cut out the view. Additionally, R. Mika and her partner no longer split the opponent's legs.

In a December 2015 article by DualShockers, Producer Yoshinori Ono stated this change was made because they wanted to avoid making players uncomfortable and that the choice was not influenced by external factors. However, in an interview featured in the Best of III webshow, Capcom's Director of Brand Marketing and Esports Matt Dahlgren stated that this change was done due to issues regarding the game's rating, as they wanted to appeal to a very wide audience and keep Street Fighter "a family-friendly franchise".

In a Gamespot article published in January 2016, Ono reiterated that the change was made to avoid making people uncomfortable. However, this time he said that the team took in consideration the criticism that certain characters were too sexualized, contradicting his earlier statement that this change was done without external influence.

When Rashid was unveiled as a playable character in Street Fighter V, his specific nationality was unknown, with players only knowing that he was Middle Eastern. However, in 2022 when the entire playable base game roster and first wave of DLC of Street Fighter 6 was leaked, it revealed a more specific country he was from, with Rashid confirmed as being Saudi Arabian.

Street Fighter series director Takayuki Nakayama revealed some concept designs by Bengus meant to represent each of divine beasts in Japanese mythology. These designs depict Byakko (the white tiger), Suzaku (the vermillion bird), Genbu (the black tortoise), Seiryu (the azure dragon), and the less often seen Koryu (the yellow dragon). These designs were meant to be used for mascots of the annual Special RAGE Cup events, which were Street Fighter tournaments held in Japan. The winner would recieve an special costume made for them.

As the RAGE Cup event only lasted for three years (2016-2018), only three of the beasts were present. It is unknown what the final concept of the blue and yellow dragons might have looked like.

According to the game's director Takayuki Nakayama, Decapre was originally meant to be in the base roster instead of Cammy. This was changed after the developers realized the latter was more essential to the game's storyline.

Decapre is not playable in the final game, instead being an NPC in the A Shadow Falls story mode.

In the Street Fighter 5 Climax Arts Plus Zero to 6 book, the game's director Nakayuki Nakayama stated that Juri Han didn't originally wear a black top underneath the catsuit, and that this was added after many people said the original design was too sexy. Juri's original design can be seen in Cammy's character story, which was included in the base game before the release of the cinematic story mode A Shadow Falls in June 2016 and Juri's inclusion as a season 1 DLC character in July 2016.

In an article by Game Informer, Street Fighter 6 Director Takayuki Nakayama stated that Street Fighter V was originally going to have six seasons of DLC before being cut down to four. However, plans changed after seeing the positive reaction fans had to Street Fighter V: Champion Edition, and an extra season was made.

If the player waits for roughly one minute and five seconds, the character G will spin around and do a pose. If G's opponent stands close to him while this happens then G will inflict 500 points of damage.

In a 2016 Famitsu interview, Capcom's Kouichi Sugiyama confirmed that Sodom from Final Fight was considered as a potential playable character for Street Fighter V. However, this never happened in the game's lifespan because the developers didn't know how to introduce the character into the story.

Eventually Sodom made a background cameo in the 2019 Capcom Pro Tour DLC stage Ring of Justice.

A port for Linux was announced to release on Spring 2016. However, the port was never heard from again after the announcement.

Menat's moveset has some divergences between the Japanese and English names. Both the Japanese and English names are filled with references to Egyptian mythology:

•Overflowing Nile in the Japanese version is ナイルの氾濫 Nairu no hanran (“Flooding of the Nile”). Nile floodings have exceptional importance for both ancient and modern Egyptians.

•Wisdom of Thoth was ジェフティの知恵 Jefuti no chie, “Wisdom of Thoth”. This discrepancy in spelling is due to the Japanese using one of the most common of Thoth’s transliterations, from his ancient Egyptian name ḏḥwty, also pronounced as Jehuti amongst other spellings.

•Left Eye of the Lion is 獅子の左目 Shishi no hidarime (“Lion Left Eye”, or “the Left Eye who is a Lion”). This alludes to Sekhmet, the lion goddess of war and destruction.

•Judgement of Anubis is 黒犬の審判 Kuroinu no shinpan ("Judgement of the black dog"). The Japanese name comes from the fact that he has a jackal’s (or black dog) head.

•Divine Retribution is a generic adaptation of the original 罪人を喰らう顎 Zainin wo kurau ago (“The jaws that eat the sinner"), an allusion to the goddess Ammit, the monster who devours the dead whose heart ends up being heavier than the feather of Ma'at.

•Khamun Kick is カーメンキック Kāmen Kikku, and derives from a common liberty the Japanese took with Ancient Egyptian language: coming from Tutankhamun's name, the most famous of all the pharaohs. His name in Ancient Egyptian is Twt ˁnḫ Jmn, "living" ˁnḫ, better known as ankh) "image" (twt) "of Amun" (Jmn). Amun's name was written first for respect towards the god, even if it was pronounced last. Given that Tut, Ankh and Amun are single words, "Khamun" doesn't make sense in context. Nevertheless, Japanese already popularised the use of カーメン kāmen as an ancient Egyptian reference, maybe prompted by the fact that the Japanese 仮面 kamen means "mask" and Tutankhamun's funerary mask is well known.

•Guardian of the Sun is in Japanese 太陽の守護者 Taiyō no shugosha, a direct translation. This references Khepri, the beetle Sun god. Khepri rolls the Sun across the sky, and he is visible on Menat's nape.

•The Nefertem is in Japanese ウン・ネフェル Un - Neferu. Nefertem is the lotus god of scent and good perfumes, as well as the son of Sekhmet. On the other hand, the Japanese name doesn't actually reference Nefertem, because the title wnn nfr, variously transliterated "Wenennefer", "Wenufer" or Unnefer, "The perfect one", "The happy one", is one of the epithets of Osiris.

Contrary to popular belief, Menat's name doesn't come from Arabic, even though that's the language spoken in modern-day Egypt. The character's name actually comes from "menat", a necklace which was used in ancient Egypt as a musical instrument for cultic dances and religious processions rather than a necklace proper.

In the 1.04 update, Cammy's leotard costume removed her nipples from her 3D model.

The 8th color scheme for Akira's default costume is based upon Linn Kurosawa from the Capcom beat em' up game Alien vs. Predator.

Pre-release footage of the game's story mode shows Spoiler:the death of the scientist in graphic detail, with the victim being melted. In the final release of the game Spoiler:the screen fades to black during the character's death.

According to Street Fighter V director Takayuki Nakayama, Laura's Sunset Wheel special move is based on the Sunset Splash move used by Gunloc from the Slam Masters series.

Sakura's design had gone through several different changes during it's development. Among those scrapped concepts include a Motion Capture actress and a Mountain Climbing Guide.

The interaction between Abigail and Juri during the former's characters story varies between regions.

On the Japanese version, Juri mistakes Abigail's onomatopoeic sounds of a car engine for the word ブス (busu; "ugly"). Because the pun has no meaning in English, this line of dialogue was changed to Abigail talking about feeling like a flat tire, only so that Juri would overhear this and confuse it with her being called flat.

Menat's design had gone through several different changes during it's development. Among those scrapped concepts include being a "Pizza Assassin" whose personality and mannerims were based on B.B Hood/Bulleta from the Darkstalkers series, a delinquent named Rita and a magician; during this stage of development she was meant to be an Italian like Rose. Later on she was considered to use other objects to attack, including smoke, golden dust, and being a tahtib fighter that uses a staff; this is the stage in which Capcom settled for Menat to be an Egyptian.

The 13th color scheme for Menat's battle costume is based upon a similar costume wore by Milla Jovovich's character Leelo in the 1997 film The Fifth Element.

M.Bison has an unused teleport move that he could use on V-Trigger, allowing him to transport him behind, in front of, or above the opponent. The move was removed in the final release because it was deemed too strong, with the only remnants being found in the game files.