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Before Tobey Maguire was called in to voice Spider-Man, Josh Keaton (best known for voicing Spider-Man in The Spectacular Spider-Man) was called in to replace him. When Tobey was brought in to reprise the role, Josh's audio was instead used for Harry Osborn in the playable Green Goblin mode.
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If you put in the cheat code "girlnextdoor" you can play the game as Mary Jane Watson. At the end of the game, where Spider-Man and Mary Jane usually kiss, Mary Jane will kiss herself. This code was removed from later versions of the game, presumably because of the lesbian kiss in an E-rated game.
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