There are actually numerous differences between the NTSC and PAL versions of Super Smash Bros. Melee. Many characters and their moves were tweaked to rebalance the game.

The language setting in the PAL version can be switched between English, French, German, Spanish and Italian, with the French and German settings having new voice overs for character name changes during character selection. In order to fit these additional languages on the disc, the Japanese language option and the Special Movie were removed.