If The New Challengers release of the game detects that the cartridge ROM is too large or not mirrored correctly, which is usually caused by use of a cartridge copier, the game will completely black out the screen some time after starting a match.

On the arcade version of "Super Street Fighter II: The New Challengers", Cammy's ending has an error in her dialogue, her line reads; "WAIT! IF WHAT HE". The end of the line is supposed to read "SAYS IS TRUE...", but it was cut off, even though the whole sentence is still inside the data.

This was corrected in "Hyper Street Fighter II", but with a comma instead of ellipses.

On the arcade and Genesis versions of Super Street Fighter II: The New Challengers, Chun Li's ending shows her punching a man with blood spraying from his mouth. In the SNES version the blood was recolored to censor it.

In Zangief's ending on the arcade and Genesis versions of Super Street Fighter II: The New Challengers, there's a close-up of ex Soviet President Mikhail Gorbachev's face, but it was removed on the SNES.

In the arcade and Genesis versions of Super Street Fighter II: The New Challengers, Balrog's quote when he wins is "My fists have your blood on them.", but on SNES, this was changed to "Get up you wimp!".

In the arcade and Genesis versions of Super Street Fighter II: The New Challengers, characters' defeated portraits show blood and gore. This was removed in the SNES release.

In the first three versions of Street Fighter II, "World Warrior", "Champion Edition" and "Hyper Fighting", Ryu and Ken's Hadoken sprites would sometimes appear orange. Developer Akira Nishitani confirmed that this was added as an Easter egg, and wasn't a glitch as previously thought.

In later versions of the game, starting with "Super Street Fighter II: The New Challengers", Ryu would receive a legitimate orange Hadoken special move called "Shakunetsu Hadoken"

In Super Street Fighter II: The New Challengers, there is an unused graphic in the game with the name "Sarah". This may have been Cammy's early name.