The Sword of Justice legendaries are inspired by the Three Musketeers.
Cobalion, Terrakion, and Virizion are based on Athos, Porthos, and Aramis respectively, while Keldeo is similar to the youngest Musketeer, d'Artagnan.

There is an unused stone in the game's code called the God Stone. A gray recolor of the Light Stone/Dark Stone sprite, with the description "A phantom stone."

In the Café Warehouse in Nacrene city, by looking at middle or right tile of the door, pressing A will show a message saying: "It looks like a cabinet full of Pokémon goods."

TM67 Retaliate & TM94 Rock Smash both have a sprite oversight where the TM Sprite does not match the Type in the HUD.
Retaliate is a Normal move but is shown as a Dark Type in the Sprite.
Rock Smash is a Fighting move but is shown as a Rock Type in the Sprite.

Game Freak spent a year and a half developing the story and characters for Pokemon Black & White.

According to the Pokedex entry for Darumaka in Pokemon White, people used to keep themselves warm by putting its droppings in their clothes.

When Pokémon Black 2 and Pokémon White 2 first released in Japan, fake leaks were posted on various websites claiming to be ROMs of the game, but in reality contained an FMV of a parody of the theme song to the Disney Channel series Cory in the House. The parody featured several of the games' characters and other memes at the time superimposed over the actors' heads, including talk show host Stephen Colbert, a caricature of the Pokémon fan website Serebii.net with a Trollface superimposed over it, and legacy Pokémon character Gary Oak. Before the title card of the show appears at the end, a barely visible screenshot of a post from the imageboard 4chan can be seen featuring the box art of the Nintendo DS game adaptation of the show, implying that the parody and fake ROMs originated from there. The video also features several scrolling text statements including:

• "Amber killed Gary" - supposedly referring to an incident on 4chan's dedicated Pokémon board /vp/ starting on August 26, 2010 where several posters using Gary Oak and Mewtwo as avatars tried to "revive" or "kill" the anime-only character Amber from The Uncut Story of Mewtwo's Origin by trying to predict their post numbers in advance.
• "SHE IS BLACK ?!?" - referring to Pokémon Black & White Gym Leader Lenora.
• "GIANT HAIR EVERYWHERE" - on the following shot with four Bouffalants superimposed over Mount Rushmore.
• "FINAL GYM LEADER (IT HAS BEEN SEREBII CONFIRMED)" - referring to Iris, the last Gym Leader in Pokémon White and seems to be referring to leaks from the first Pokémon Black and Pokémon White games.
• "THIS FLOATING TEXT IS UP IN YO' SCREEN DAWG"
• "AMERICA" - on a shot of Stephen Colbert.

An upload of the fake ROM's FMV on YouTube dates back to September 16, 2010, two days before Pokemon Black & White's release date in Japan, and features several comments mentioning 4chan and /vp/ on top of the references in the video, suggesting that the hoax actually dates back to the release of the first Pokémon Black and Pokémon White, although discussion of this FMV from that time does not appear to have been preserved. While this ROM is also not known to be preserved (though its contents are), as recently as 2018 there have been reports of ROM dumps of Pokémon White 2 being silently modified to include Cory in the House references, including NPCs with dialogue featuring the lyrics to the show's theme song.