Nickelodeon All-Star Brawl does not feature characters from live-action Nickelodeon series. According to Ludosity CEO Joel Nyström, this was due to the developers being unable to envision movesets for live-action characters (i.e. "I'd assume they don't feature a giant, two-ton hammer suddenly produced from your back pocket") and that many of the series did not air in Sweden. When asked about live-action content in an interview, he stated


Despite this, a developer from Ludosity has claimed that a live-action character was considered in the form of Alex Mack from The Secret World of Alex Mack, portrayed by Larisa Oleynik, but this was shot down by Nickelodeon.

Although not explicitly stated, it could also be assumed that live-action characters were off the table for likeness costs, given that All-Star Brawl was initially unable to afford character voices, and that actors involved in Nickelodeon sitcoms have been known to frequently get into extreme scandals that end their careers.

Nickelodeon All-Star Brawl does, however, feature a stage based on the game show Double Dare, and multiple aesthetic references to the iconic Nickelodeon slime which debuted in You Can't Do That on Television!