Some minigames like Tug o' War, Paddle Battle, Cast Aways, Deep Sea Divers, Pedal Power, and the Mecha Fly Guy minigame caused players to resort to using their palm to rotate the hard, plastic control stick faster to win or get better results. This appears to be an intended control method as it was featured in a Japanese commercial for the game, but it was not a safe way to play those minigames, injuring players through blistering, burns, lacerations, punctures, and cuts. After over 100 complaints were made to the New York Attorney General's office, Nintendo agreed to a settlement to pay $75,000 to the office to cover their investigation into the matter, and agreed to give out padded, fingerless sports gloves to injured players who could provide proof-of-purchase, potentially giving out $80 million worth of them. However, the requirements to do so were reportedly "elaborate" and it's not known how many gloves actually reached injured players. Since the game had already sold 1.5 million units by the time this settlement was reached, a warning was published in an issue of Nintendo Power that recommended players to instead rotate the control stick with their thumb, or hold it between the thumb and forefinger. This warning was also added to the start of the Nintendo Switch Online re-release of the game, as well as Tug o' War's re-appearance in Mario Party Superstars, to protect Nintendo from legal liability when re-introducing control stick minigames to the Mario Party series.

In the Japanese release, the background in the mini-game Face Lift reads "Super Koopa 64" as opposed to "Super Bowser 64" as seen in the international releases, going by how Bowser is named Koopa in Japan.

The music that plays in the mini-game "Bobsled Run" seems to be based on the Giant Land Theme from Super Mario Bros. 3

Mario Party supports the 64DD as a possible game add-on. While the US version displays a black screen when there's a 64DD attached to the system, the Japanese and European versions actually recognize the 64DD and check for a disk. If it's the wrong disk, an error will appear in either Japanese, English, French, or German depending on the selected language.

There is a track in the Japanese version not present in the NTSC release of the game called "Move to the Mambo". It plays during the mini-games Balloon Burst and Musical Mushrooms.

Through the use of a Gameshark code, it's possible to enable a feature that ultimately went unused in the final game. After a player's turn ends, their HUD will turn yellow, and a big "NO GAME" sign will appear before moving on to the next turn, instead of playing a mini-game. If it's the last turn, a big "GAME OVER" sign will appear, and the board ending will play as normal.

Some of the game's voice clips are copied from the Japanese version of Mario Kart 64. This is true for all versions of the game.

The music that plays in the Mini-game 'Pedal Power' is a remixed version of the "Ice Land" theme from Super Mario Bros. 3.

In the Japanese version of the game, both Wario and Luigi had different "MISS" lines. If they failed or "Missed" (like got to Bowser or lost a mini-game), they would say "Oh, my god." They changed it so Wario would say "So Ein Mist!" (which means "Such A Crap!" in German) and Luigi to say, "Ohhh" instead, which would carry over to all versions of Mario Party 2.

There are a few mini-games which were cut but can still be found in the game's files. The games are All or Nothing, Tour de Mario, Bungee Jump, Same Game, and Yoshi's Tongue Meeting. Some of them are playable and can be accessed with the use of a GameShark device.