In a June 13th, 2024 interview with the Dragami Games CEO Yoshimi Yasuda published on the Gematsu website, he stated that in 2021, he asked Tomo Ikeda, one of the directors he led in the development team for the original Lollipop Chainsaw, to help with the game's remake Lollipop Chainsaw RePOP, but Ikeda turned him down due to conflicts from already leading development on a different project at that time. Yasuda still expressed that he felt very proud of his former developers for advancing in the industry and maintained a good relationship with the original game's writer Masahiro Yuki, having spoken several times with him in 2023 about RePOP and the future of Lollipop Chainsaw. He described Yuki as "something like a repository of wisdom within the team" during development, and gave Yasuda lots of proactive and stimulating opinions that were reflected in RePOP. Yasuda stated that the agenda for RePOP was to "improve on the user-friendliness" and give a more fun experience for players that were left lacking in the original game. In order to do that, he contacted the engineers who worked on the original game to provide detailed development information, like how data was handled and special processing related to Unreal Engine 3, which directors and producers would not be able to provide, and called their support "especially indispensable".

Japan got a special edition release of Lollipop Chainsaw on Valentine's Day of the year of 2013. This special edition features additional content, including a "perfect unlock code", limited edition sleeve, and two bonus DVDs. The Happy Valentine Disc has PC items such as a desktop clock, wallpapers and a library of trailers; the Premium Movie Disc contains in-game movies and a Valentine's Day comic.

DLC costumes for Juliet Starling reference several anime and manga characters, such as:
• Saeko Busujima and Rei Miyamoto from Highschool Of The Dead
• Shiro from Deadman Wonderland
• Haruna from Is This a Zombie?
• Manyu Chifusa from Manyū Hiken-chō