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During the missions in which the player Spoiler:steals cars for Devin, the garage in which the cars must be delivered to has a list of cars that Devin wishes to be obtained, written in UV pen. This is a reference to the film, Gone in 60 Seconds, in which the same tactic is used to cover up the team's act of stealing cars.
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It is possible to visit Ludendorff, North Yankton in GTA Online by glitching the game. If another player invites you to their game during the game's first mission the area can be found floating in the South-East part of the map and is traversable by the players.
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The museum called Bishop's WTF?! on Hollywood Boulevard and North Highland Avenue is a parody of the real life museum Ripley's Believe it or Not!
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One of the Gold medal objectives in the mission "Did Somebody Say Yoga?" is called "Praise The Sun!". This is a reference to a popular phrase used in the game Dark Souls.
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During the mission "Father/Son", when Spoiler:Franklin throws someone off the boat, he'll make the Wilhelm scream, a very popular stock sound effect in movies. It can also be heard at the movie studio in the game.
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In an interview with "USA Today", Ned Luke stated that he gained 25 pounds to portray his character, Michael De Santa.
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One of the Gold medal objectives in the mission "By the Book" is called "Don't Stop Me Now". This is a reference to the song "Don't Stop Me Now" by Queen.
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The 4th heist mission "The Paleto Score" is loosely based on the 1997 North Hollywood Bank Robbery.
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In the mission "Did Somebody Say Yoga?" Amanda originally wore a white bathrobe, as seen in Trevor's character trailer.
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The name of Trevor Phillips' business, TPI Enterprises, is a real Australian company that processes opium poppies.
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