Some of the characters have different names across regions.

•The playable characters Sho, Jennety, and Hoover were renamed to Ginzu the Ninja, Mack the Knife, and Baby Head respectively.

•The 7th stage boss Blood was changed to Boots. This change was exclusive to the SNES version.

•The final boss Genocide was changed to Scumocide.

The outfits of the female enemies Carol and Brenda show more skin in the arcade version, whereas in the SNES version they are more covered up.

Ginzu's profile in the arcade version mentions he's capable of dissecting his enemies while Mack's says he can melt them. These details were removed from the SNES version.

Blood and pink smoke (the latter happens when Mack hits the enemy) where removed from the SNES version.

Most of the enemies can be dissected if they recieve a lethal hit from Ginzu. This does not happen in the SNES version.

Most enemies melt away after recieving a lethal hit from Mack. This does not happen in the SNES version and instead they simply drop to the ground.

At the beginning of the level you can see two enemies smoking cigarettes while squatting. This does not happen in the SNES version.

The enemy known as Mardia attacks by spitting green slime to the player. Because the attack makes it look like she's vomiting, this was changed in the SNES version where she throws bombs to the player instead.

Some of the enemies in the game have Ride Armors which the player can also control. This feature wasn't available in the SNES version, with the Ride Armors being completely removed.

If the player lands a lethal blown with Captain Commando's flamethrower or similar fire attacks the enemy will burn until they turn into ash. This does not happen in the SNES version, where the burned enemies stay on the ground before dissapearing.

In the arcade version, there are armed enemies which drop fire arms when they die, which can later be used by the player. These enemies along with the usable weapons were removed from the SNES version.

It is often said that Mega Man was once used as Capcom's mascot in the 1980s, in a similar way to how Nintendo and Sega use Mario and Sonic respectively. Like many other statements of platforming characters being used as corporate mascots, this is untrue, as Mega Man has never been used to promote the wider Capcom brand of software outside of his own games or crossovers in which he appears. However, Capcom did have a mascot in the 1980s: the titular hero of Captain Commando - many earlier NES Capcom games were branded as part of the "Captain Commando Challenge Series", including licensed titles such as DuckTales, with game manuals having signed messages "written" by Captain Commando. Despite this, Captain Commando was never released on the NES.

Capcom's former community manager Seth Killian addressed Capcom's current lack of a mascot and Mega Man's use as an unofficial mascot on the Capcom-Unity forums in 2009: