Originally there were plans to have Bayek incapacitated or killed early on in the game, with his wife Aya becoming the main character of the game. This idea was scrapped for then-unknown reasons, but was later revealed by anonymous Ubisoft employees in a 2020 Bloomberg article investigating internal abuse and sexism among the company's executives.

At the bottom of the canal outside the city of Letopolis, a huge rock in the shape of the spaceship the TARDIS from the television series Doctor Who can be found.

Audio company Focal, together with French jeweler Tournaire, produced a set of 18-carat Bluetooth gold headphones selling at €50,000 to tie-in with the game's release. Called the Assassin's Creed Origins Utopia headphones and based on Focal's Assassin's Creed Origins Listen Wireless headphones, the set features Egyptian iconography with only 10 produced in total. The headphones were sold exclusively by Tournaire at their Paris boutique and also come displayed with a bronze bust of Bayek, the gam's protagonist.