In response to fans of Antonblast and Pizza Tower attempting to start an arbitrary rivalry between the two games, Antonblast creator Tony Grayson tweeted "Why not both?" with an illustration of Anton and Peppino deep kissing.

Jewel Ghoul's boss fight opens with him striking a pose where he holds one hand in front of his chest and points the other at the viewer while leaning back. This plus his outfit – a bright, colorful zoot suit – references a shot of Daffy Duck from the 1946 Looney Tunes short "Book Revue". Meanwhile, the smaller versions of himself used as flunkies appear to be modeled on another zoot suit worn by Tom in the 1944 Tom and Jerry short "The Zoot Cat". The juxtaposition of these references appears to nod to an internet meme which portrays these renditions of Daffy and Tom as JoJo's Bizarre Adventure characters, owed to their bright outfits and stylized poses unintentionally paralleling JoJo author Hirohiko Araki's distinctive art style.

Freako Dragon's boss fight ends with Anton/Annie grabbing him by the horns and forcing him to crash into a sports arena in the middle of Brazil (which is depicted in-game as an isolated landmass). This references an internet meme where individuals are sent to the country against their will, parodying the perceived widespread tendency of Brazilian social media users to request that celebrities visit them.

Originally, Boiler City was intended to have a yellow sky, more closely resembling its incarnation from Antonball Deluxe, but between the release of the Dynamite Demo and the One Blast Demo, it was changed to a green sky. Series creator Tony Grayson acknowledged this change in a YouTube video filmed while presenting the game at PAX West, parodying a viral video originally filmed in September 2018 during a large fight at a shopping center in White Marsh, Maryland. In the video, a man witnessing the fight jokingly creates a fake narrative about it being caused by the late discovery that the animated series Ed, Edd n Eddy ended in 2009, shortly before the incident devolved into gunshots and a stabbing that left one person injured. The timing of the gunshots in the viral video was reframed in Grayson's parody as someone unconvincingly hitting another person with a folding chair and kicking them while laughing.

The "A9@:$))2;$,!,7nJjjj171;" skin parodies various clichés in the "cursed video game" subgenre of creepypastas, online ghost stories shared around online forums and imageboards. In addition to its garbled name, which mimics the appearance of corrupted text, the color palette features garishly bright and mismatched colors as if it is glitched, while the skin's description is a lengthy, all-caps warning claiming that the player has invoked a curse against themself. Notably, the warning goes on for so long that it is cut off by Annie's sprite, and the full text can only be read by hacking the game.

The choice to give each room in Antonblast its own individual name was inspired by Commodore 64 single-screen platformers, particularly the bootleg game Snoopy by Radarsoft BV.

Anton was originally supposed to be an alcoholic in Antonball Deluxe, but the publisher forced the developers to remove that element, and he would drink sodas and floats instead. Anton would be made a drunkard in Antonblast, and the plot of the new game would revolve around rescuing his collection of "spirits".

Brendan O'Brien, the original voice of Crash Bandicoot from the character's inception until 2001, was in talks to do voice work for Antonblast, but unfortunately passed away in March 2023 before he could record any lines.

In a trailer for the game and the design and description of the Spray Can costume "Anton's Daughter", it is jokingly implied that Anton is the father of Amy Rose from the Sonic The Hedgehog series. This is a reference to a fan art trend following the reveal of Sonic Origins, where fans would portray Anton as a friend or family member to Amy after her spinning hammer attacks shared a resemblance to Anton's hammer attacks.

Within the game's data is an incomplete cutscene depicting Anton interrupting Satan's game of Pachinko; the sequence is fully animated and voice acted, but lacks sound effects. The sign on top of the Pachinko machine, "PaFREAKO," indicates that the cutscene was likely intended to precede the Freako Dragon fight.

The opening lines to the song "Idle Hands (The Mysterious Glasshouse)" feature the lyric "Check it out, I'm in the house like carpet." This is a reference to the same opening line of the song "Burning Men's Soul" from the soundtrack to "Persona: Trinity Soul", an anime based on the Persona series.

The alternate palettes "Warrior Land" and "SS Syrup" are both references to the Wario Land series, the primary inspiration for Antonblast. Their descriptions also allude to this, with the former stating "We owe it all to him" (referencing Wario, the titular protagonist of the series), and the latter stating "A wardrobe fit for a Captain" (a reference to Captain Syrup, the main antagonist of the first two Wario Land games).

According to creator Tony Grayson, possibly in a joking manner, the Anton characters are all multicoloured as a result of a nuclear war that left only Japan and their home country of the Backburner Peninsula, and are not meant to be any real-world enthicity. Grayson jokingly compared the skin colors of the Anton characters to The Groovenians, a 2002 Cartoon Network pilot that was not picked up for a series.

The music track "Super Gangston!" in Antonball Deluxe is a highly distorted early version of "Dynamite Man" from Antonblast, which had not been officially revealed at the time of the game's launch.