The village of Arefu is an actual real-world place inside of Romania, most well known for its proximity to the former castle of Vlad III, who is also known as "Dracula" and "Vlad the Impaler." It is also the main stage for the questline "Blood Ties", which deals with a group of cannibals who believe themselves to be vampires. One of the NPCs involved with the questline, Lucy West, is likely based off of Lucy Westenra, a character from Bram Stoker's Dracula.

The group of vampires call themselves, "The Family", are likely a reference to the 1971 Charlton Heston film The Omega Man, featuring a nocturnal breed of pale, vampyric mutants that live underground, referring to themselves as "The Family." Lastly, the password to open a locked-door containing one of the quest-line NPCs is "Vespertilio," which is a genus of the bat family.