This game was released before the second Yu-Gi-Oh series was televised, but includes many of its characters. For reference, this game was released December 9th 1999 in Japan. All dates are from their Japanese release, as this is where they originate.

•Pegasus appeared in the first episode of the second series, April 18th, 2000.
•Rex and Weevil appeared in the 2nd episode, April 25th, 2000.
•Mai Valentine appeared in the 3rd, May 5th 2000.
•Bandit Keith appeared in the anime in the 16th episode, August 8th 2000.
•Ishizu Ishtar, Priest Seto, and Pharaoh Atem (whom the player controls) all appeared in episode 52, April 24th 2001.
•Shimon Muran (Simon in the game) would make his first appearance in episode 201 on April 21st 2004.

Ishizu as she appears in the game, uses a different name from what she was given in the series. In game, her name is Isis.

Her appearance is slightly different and her personality is more fierce, greatly contrasting to how she appears in the anime and manga.

In Yu-Gi-Oh! Forbidden Memories, the Rod is shaped and colored slightly different. It is also owned by Kaiba in the modern day instead of Marik.

Despite being in this game, the card Meteor B. Dragon would not see release in the TCG (Trading Card Game, basically everywhere but select Asian countries) until 13 years after its release in the OCG (select Asian countries, including Japan and Korea).

Using a specific code with a Gameshark cheat device, it's possible to view your opponent's cards in their hand during play. Utilizing this cheat, it's been discovered that the CPU opponents are programmed with an unfair advantage allowing them to change the cards drawn from their deck into entirely different cards to better suite the course of a match (i.e. changing an unnecessary Trap or Spell card into a Monster card that has high enough ATK points to destroy a powerful Monster card the player may have placed on the field the turn prior).