As a tie-in to the remake of the game, a sequel to the original side-story "Wesker's Report" was made, named "Wesker's Report II." Unlike the first Report, the second was not a video but as text on various backgrounds relating to the Spencer Mansion Laboratory. The Report in this case was written by Wesker himself addressed to his cohort Ada Wong, and details Wesker's backstory set during the 20 years leading up to the 1998 mansion incident.

The Report also details the backstory of Lisa Trevor, the monster encountered in game, as well as background info on William Birkin and the Ashford family, as well as Birkin's jealousy towards the child prodigy Alexia Ashford. The Nemesis parasite is also mentioned in the report as well.