The title card for the "Gnome Forest" level became the subject of the "Lario" meme, which features an edited version of the card with the word "Lario" above the characters' heads as a mash-up of "Sneaky Snitch" by Kevin MacLeod and "Superstar" by Young Thug. This meme would go on to be referenced within Pizza Tower itself, with Gnome Forest's secret music being renamed "Everybody Wants To Be A Secret" after the meme became popular.

If the player idles on the main menu for about 40 seconds without inputting anything, Peppino will eventually jumpscare them, causing the game to close itself.

In response to fans of Antonblast and Pizza Tower attempting to start an arbitrary rivalry between the two games, Anton creator Tony Grayson tweeted "Why not both?" with an illustration of Anton and Peppino kissing.