The arcade release of Nicktoons Racing is a modified version of the PC release running on a Windows XP computer bolted into the cabinet. Some modifications are made for the arcade setting, such as a selectable time limit, but the biggest changes are the omissions of the game's opening cutscene, Stimpy from The Ren & Stimpy Show as a racer, and the Gritty Kitty item from that series. While the Race Madness track also based on the series remains in the arcade version of the game, Stimpy and the Gritty Kitty item were most likely removed due to it releasing in 2003, the same year as the adult-oriented Ren & Stimpy: Adult Party Cartoon reboot. The opening cutscene appears to have been removed due to it requiring Windows Media Player, but may have also been removed due to difficulty in editing Ren & Stimpy elements out of the opening cutscene. The removed content is still within the files, and simply disabled.

The Hasbro Interactive logo that plays in the PC version is desynchronized in both the video being slower than normal, and the audio starting later.

The character voices in Nicktoons Racing are all existing clips from their shows as opposed to original voice work. However, multiple character voice lines, particularly those of Angelica, Darwin, and Stimpy, have background music or sound effects from the original scenes left intact instead of using the original masters or digitally removing the noise. Additionally, one of Arnold's voice lines is from Harold and one of Tommy's voice lines is from Chuckie.

Inside the PC version's files is an unused image of a badger wearing a green suit. This might have a relation to Jeff Badger, who is listed as "Morale Consultant" in the credits.