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According to the developers of the game, Iris was given a larger role in this game as X and Zero's Navigator to make up for everything they put her though in Mega Man X4.
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Due to a translation error, the "Reploid Research Laboratory" was written as "Reploid Research Lavatory" in Mega Man Xtreme 2's opening cutscene. This error wasn't fixed in the 3DS Virtual Console release.
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