Besides being based on Part 3 (Stardust Crusaders), this is the first game to have elements from more than one JoJo saga:

• Part 1: Wang Chan as Shadow Dio's "child" form during Alessi's stand ability, a shot of the Stone Mask appears when a character is stand crashed, and both versions of Dio have Space Ripper Stingy Eyes as a special move.
• Part 2: Young Joseph is a playable character, Caesar appears in the Young Joseph's special move that contains several manga panel flashbacks as well as Lisa Lisa doing the same for Old Joseph's version, the Red Stone of Aja is used as one of Young Joseph's supers and the crossbow he used against Wamuu, as well as the coke bottle during his introduction scene, appears in his moveset.
• Part 4: The arrow appears during Polnareff "Requiem" super, one of Jotaro's alternate color scheme recolours his coat, hat and pants white, much like his Part 4 outfit and in one of Dio's alternate color scheme, The World is pink and blue giving it an appearance similar to Crazy Diamond.
• Part 5: Silver Chariot Requiem appears as a super combo for Polnareff and one of his win quotes translates to "We'll meet again in the future...in Italy".