In Vault 87 is a Super Mutant that calls himself "Fawkes" locked in Isolation Room 05.

This is a reference to the comic-book V for Vendetta, where the main character (V) is originally a prisoner from "Room 5" at Larkhill Internment Camp. After escaping, V dons the infamous mask of Guy Fawkes, the real life British revolutionary known for the failed Gunpowder Plot in 1605.

Both V and Fawkes gain super strength and intellect after their experimentation, which is rare as most Super Mutants only gained super strength but suffered mental drawbacks (or even died), and in the case of V, most subjects did not survive the experiments.