Bayonetta and Dante from the Devil May Cry series share several quotes. Bayonetta and Dante both say "Let's Rock Baby" in a fashion similar that Dante did in the first Devil May Cry game. They also share the quote "Flock off, Feather face!" both said to a bird like boss.

At the start of Bayonetta, a funeral is held for a notorious criminal known as "Eggman the Destroyer". This, to a Western audience, seems like a very obvious reference to Sonic the Hedgehog's main antagonist Dr. Eggman, as Bayonetta was published by Sega. However, series creator Hideki Kamiya claimed that he randomly chose the name Eggman and was not aware that there existed a popular Sega character with the name, choosing to leave it as is in the hopes that fans would "get a kick out of that".

During any cutscene where Bayonetta has a lollipop, if you hold down a specific button before the candy head of the lollipop first appears, you will gain the effect of a specific lollipop item available in the game's stores, and this is reflected in the cutscene by changing which lollipop flavor is shown:

• A for Green Herb lollipop (recover health)
• B for Bloody Rose lollipop (temporary damage boost)
• X for Purple Butterfly lollipop (recover magic)
• Y for Yellow Moon lollipop (gain armor)

It is pertinent that you press and hold the desired button before the candy part of the lollipop is actually seen in the cutscene to ensure the trick works. For example, in Chapter IV: The Cardinal Virtue of Fortitude, when Bayonetta walks into the colosseum, you can see that she is holding a lollipop, but you can only see the stick at first, meaning there's still time to perform the trick. If performed correctly, the lollipop head will be revealed as the one you have chosen. You can also skip the cutscene while still holding the button in order to keep the effect. Unlike normally using a lollipop item, performing this trick does not remove points from your score in a chapter.

Going off of the colors of each lollipop that are used for each face button, they match up with the Xbox 360 controller's color scheme, possibly being a remnant of Platinum Games primarily developing Bayonetta for the Xbox 360. This feature would not be carried over into subsequent Bayonetta games.